Predictive factors for complete removal in soft tissue sarcomas: A retrospective analysis in a series of 592 cases

1997 ◽  
Vol 65 (3) ◽  
pp. 175-182 ◽  
Author(s):  
Xavier Sastre-Garau ◽  
Jean-Michel Coindre ◽  
Ariane Leroyer ◽  
Philippe Terrier ◽  
Lilianne Ollivier ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Retrospective Analysis ◽  
Predictive Factors ◽  
Soft Tissue Sarcomas ◽  
Complete Removal

scholarly journals CUL4A, ERCC5, and ERCC1 as Predictive Factors for Trabectedin Efficacy in Advanced Soft Tissue Sarcomas (STS): A Spanish Group for Sarcoma Research (GEIS) Study

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1128 ◽  
Author(s):  
David S. Moura ◽  
Paloma Sanchez-Bustos ◽  
Antonio Fernandez-Serra ◽  
María Lopez-Alvarez ◽  
José L. Mondaza-Hernandez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Soft Tissue ◽  
Cell Lines ◽  
Predictive Factors ◽  
Excision Repair ◽  
Soft Tissue Sarcomas ◽  
Predictive Biomarkers ◽  
Progression Free Survival ◽  
Expression Levels ◽  
Protein Levels

A translational study was designed to analyze the expression of nucleotide excision repair (NER) and homologous recombination (HR) genes as potential predictive biomarkers for trabectedin in soft-tissue sarcoma (STS). This study is part of a randomized phase II trial comparing trabectedin plus doxorubicin versus doxorubicin in advanced STS. Gene expression levels were evaluated by qRT-PCR, while CUL4A protein levels were quantified by immunohistochemistry. Expression levels were correlated with patients’ progression-free survival (PFS) and overall survival (OS). Gene expression was also evaluated in cell lines and correlated with trabectedin sensitivity. In doxorubicin arm and in the whole series, which includes samples from both arms, no significant differences in terms of PFS were observed amongst the analyzed genes. In the group treated with trabectedin plus doxorubicin, the median of PFS was significantly longer in cases with CUL4A, ERCC1, or ERCC5 overexpression, while BRCA1 expression did not correlated with PFS. Gene expression had no prognostic influence in OS. CUL4A protein levels correlated with worse PFS in doxorubicin arm and in the whole series. In cell lines, only overexpression of ERCC1 was significantly correlated with trabectedin sensitivity. In conclusion, CUL4A, ERCC5, and mainly ERCC1 acted as predictive factors for trabectedin efficacy in advanced STS.

scholarly journals Retrospective Analysis of Ifosfamide Encephalopathy in Patients with Bone and Soft Tissue Sarcomas

2012 ◽  
Vol 23 ◽  
pp. xi130
Author(s):  
K. Takada ◽  
R. Takimoto ◽  
T. Yoshinaga ◽  
S. Iyama ◽  
K. Ono ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Retrospective Analysis ◽  
Soft Tissue Sarcomas ◽  
Ifosfamide Encephalopathy

scholarly journals What is the role of routine follow-up for localised limb soft tissue sarcomas? A retrospective analysis of 174 patients

2014 ◽  
Vol 110 (10) ◽  
pp. 2420-2426 ◽  
Author(s):  
C Rothermundt ◽  
J S Whelan ◽  
P Dileo ◽  
S J Strauss ◽  
J Coleman ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Retrospective Analysis ◽  
Soft Tissue Sarcomas

scholarly journals Retrospective Analysis of 498 Primary Soft Tissue Sarcomas in a Single Turkish Centre

2012 ◽  
Vol 13 (8) ◽  
pp. 4125-4128 ◽  
Author(s):  
Berna Bozkurt Duman ◽  
Meral Gunaldi ◽  
Vehbi Ercolak ◽  
Cigdem Usul Afsar ◽  
Berksoy Sahin ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Retrospective Analysis ◽  
Soft Tissue Sarcomas

Retrospective analysis of management and outcome of advanced soft tissue sarcomas (STS) with rare histology.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e23564-e23564
Author(s):  
Atul Sharma ◽  
Naresh G ◽  
Aditi Aggarwal ◽  
Adarsh Barwad ◽  
Ekta Dhamija ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Retrospective Analysis ◽  
Soft Tissue Sarcomas
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